Angioimmunoblastic T-lymphoma: overview, single centre experience and case report of the sequential development of diffuse large B-cell lymphoma
Abstract
Angioimmunoblastic T-cell lymphoma is a rare, aggressive lymphoproliferative disease that arises from T-cells derived from the germinal centre. It is usually diagnosed in advanced stages but B-symptoms, oedemas and various skin changes can occur as initial signs of the disease and may be even more significant than lymph node or organ involvement.
These general symptoms can mask the lymphoma and delay diagnosis. Remarkably, a B-cell lymphoma may develop during the course of this disease, usually diffuse large B-cell lymphoma.
In this article, we present a general overview, single centre experience from the past 16 years and a case report of diffuse large B-cell lymphoma occurring during the treatment of angioimmunoblastic T-cell lymphoma in a single patient.