Abstract
Inflammatory bowel diseases (IBD) may also manifest on the skin. Skin manifestation can occur in 22-44% of patients with Crohn's disease (CD) and it is the most common extraintestinal manifestation of CD.
Specific lesions, reactive lesions, and associated diseases are among the skin manifestations of CD. Specific lesions have the same histopathological findings as CD.
Erythema nodosum, pyoderma gangrenosum, and aphthous stomatitis are among the reactive lesions of CD and each presents a different histopathological picture. Psoriasis, atopic dermatitis, and hidradenitis suppurativa are also diseases associated with CD.
Peristomal dermatitis and dermatosis due to malabsorption and malnutrition are another issue in CD patients. Dermatosis caused by IBD treatment is another important problem in patients with IBD.
Skin side-effects can occur in 20% patients undergoing biological treatment. The most common dermatosis in these patients is atopic dermatitis, paradoxical reactions, and bacterial skin diseases, such as pyoderma.
A paradoxical reaction is defined as the induction or exacerbation of a disease by a drug(s) approved for the disease. In the case of skin manifestations, it is not always necessary to withdraw the prescribed drug.
Given the relatively high occurrence of diverse skin reactions in patients suffering from IBD, close cooperation between gastroenterologists and dermatologists is highly recommended.