Abstract
Multiple sclerosis (MS) is a chronic disease of the central nervous system leading primarily to motor and sensitive disability. Cognitivedeficit is present in almost 70 % of patients with MS and is detectable even at the earliest stage of MS - in patients with clinicallyisolated syndrome (CIS).
Because cognitive deficit has an important impact on a patients' quality of life, it is important to focus ontheir potential cognitive deficit in routine clinical practice. The aim of this review is to summarize new findings about cognitivedeficit and neuropsychiatric symptoms in patients with MS and to describe how to manage cognitive deficit in patients with MS.