Abstrakt
Microbial colonization of biomedical devices is a recognized complication contributing to healthcare-associated infections. One of the possible approaches to prevent surfaces from the biofilm formation is antimicrobial photodynamic inactivation based on the cytotoxic effect of singlet oxygen, O-2((1)Delta(g)), a short-lived, highly oxidative species, produced by energy transfer between excited photosensitizers and molecular oxygen.
We synthesized porphyrin-based covalent organic frameworks (COFs) by Schiff-base chemistry. These novel COFs have a three-dimensional, diamond-like structure.
The detailed analysis of their photophysical and photochemical properties shows that the COFs effectively produce O-2((1)Delta(g)) under visible light irradiation, and especially three-dimensional structures have strong antibacterial effects toward Pseudomonas aeruginosa and Enterococcus faecalis biofilms. The COFs exhibit high photostability and broad spectral efficiency.
Hence, the porphyrinic COFs are suitable candidates for the design of antibacterial coating for indoor applications.