Abstract
Beauveriolide I, of >98 % purity (HPLC); CAS 154491-55-1; the cyclopeptide cyclo(-3OH4MeC8a1-Phe2-Ala3-Leu4-), where: -3OH4MeC8a stands for the 3(R)-hydroxy-4(S)-methyloctanoic acid residue; -Phe, L (S)-phenylalanine; -Ala, L (S)-alanine; -Leu, D (R)-leucine The substance was isolated by a newly developed procedure from the production strain of the fungus Beauveria (monosporic isolate). It is produced at a purity > 98%.
The physicochemical properties of the product have been described in detail in the accompanying safety data sheet (SDD) and the functional sample certificate. The substance is the major bioactive metabolite of several species of entomopathogenic fungi of the genus Beauveria, Isaria or Paecilomyces.
BVD-I inhibits the enzyme acyl CoA: cholesterol acyltransferase (ACAT1 and ACAT2) and is included in a new class of substances that reduce the accumulation of β-amyloid peptides in the brain, one of the major manifestations of Alzheimer's disease. New experiments show that the substance has the potential to slow down some neurodegenerative processes during aging.