Abstrakt
Aim:The aim of this study was to summarize clinical, radiological and pathological data on calcifying pseudoneoplasm of the neural axis (CAPNON). Methods: A case report of a female patient with CAPNON is presented.
In addition, all CAPNON patient case histories published in English language are included. Articles were identified via PubMed searches using the following key words: calcifying pseudoneoplasm, calcifying pseudotumour, brain stone, cerebral calculi and fibro-osseous lesion.
All cases referenced within the identified publications are also included in this review. Results: Seventy two cases were identified, including our case report.
Of these, 62% were intracranial, 31% spinal and 7% were located in the cranio-cervical junction (CCJ).The mean age of the CAPNON patients was 45.6 (range 2-83) years. 74% of intracranial CAPNON were supratentorial and 26% were infratentorial. Symptoms of intracranial CAPNON included epilepsy in 33.3%, headaches in 24% and posterior fossa symptoms in 16.7%.
The majority of patients with epileptic seizures had lesions in the temporal lobe (50%). Pain was the dominant symptom in 82% and gait disorder in 27% of spinal CAPNON cases.
Pain was the dominant symptom (80%) in CCJ CAPNON. Conclusion: CAPNON is a rare, benign, slowly-growing lesion of the central nervous system.
In the majority of cases, location is intracranial and there is a slightly higher prevalence in men. The origin of CAPNON remains unclear.
CAPNON should be considered whenever a CT scan reveals a calcified lesion combined with hypointensity on T1 and T2-weighted MRI. Radical removal is the treatment of choice.
Incidental lesions must be monitored, as they may grow and become symptomatic.