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Imprinting of energergy homeostasis

Publication at Third Faculty of Medicine |
2015

Abstract

In 21st century the healthiness of individuals and whole society is mostly affected by prevention of lifestyle diseases mainly represented by obesity. Common obesity becomes the most important medical issue of contemporary humankind.

Serious consequences are to be awaited since the pandemic of childhood obesity. Genomic program of energy homeostasis based on development of obesity causing surroundings is exposed limitless energy intake with pathophysiologic consequences, which are continously being uncowered.

Obesity causing surroundings negativly interfer not only with social macroecosystem but also with perinatal and postnatal microecosystem in terms of connection between mother and child. Effect of external surroundings on genomic expression of energy homeostasis is applied via programing in these days.

It sets basic energetic metabolic processes and in subcortical centers sets preferential eating habits. Programing primary modifies fertility in connection to current conditions of external surroundings.