Publication at Second Faculty of Medicine |
2018
Abstract
Fibrous dysplasia is a benign bone disease occuring in mono- or polyostotic form that affects predominantly long bones of the limbs and cranium. Its etiology is associated with gene mutation on the 20th chromosome leading to the failure of bone formation and remodeling.
Most lesions are asymptomatic, the rest is manifested by pain, the development of deformity or pathological fracture. Medication treatment can help reduce pain, surgical therapy involving biopsy is indicated for the eradication of symptomatic lesions, fracture repair and deformity.