Publication at Faculty of Science |
2018
Abstract
Terconazole is a triazole antifungal agent, which seems to disrupt cell wall synthesis in fungal by inhibiting biosynthesis of ergosterol or other sterols. In this study, electrochemical behaviour of terconazole was studied using cyclic voltammetry and differential pulse voltammetry on a boron doped diamond electrode.
It is oxidizable in aqueous solutions in pH range from 2.0 to 12.0 due to the presence of the piperazine moiety in the molecule. Anodic activation of working electrode was used to ensure good repeatability of measurements.
Optimal conditions were found for determination of terconazole in 0.1 mol L(-1) phosphate buffer pH 7.2 within the concentration range from 2.10(-7) mol L(-1) to 1.10(-4) mol L(-1).