The broad present interest in clinical guidelines about HTN in children and adolescents stems from the desire of healthcare professionals to offer, and of patients to receive, the best possible care, that is, a care that is consistent, efficient, and closes the gap between what clinicians do and what scientific evidence supports. The guidelines that have been published over the years have importantly expanded knowledge to the field and have boosted the interest, not only of epidemiologists, but also of pediatricians and basic researchers.