Sinusoidal obstruction syndrome induced by monocrotaline in a large animal experiment - a pilot study

Abstract

The aim of this study was to establish a large animal model of SOS, which would enable further study of this disease and facilitate translation of experimental outcomes into human medicine. We established a large animal model of SOS induced by monocrotaline administration.

This model can contribute to research of therapeutic modalities for this disease or to evalution of surgical Treatment of patients with SOS.

Keywords

• Sinusoidal obstruction syndrome
• monocrotaline
• oxaliplatin
• hepatotoxicity
• experimental model