Brain biopsy represents an important technique in the verification of focal brain processes. Nowadays, either framebased or frameless stereotactic biopsies are performed.
Open biopsy from a craniotomy is reserved for cases of non-conclusive stereotactic biopsy that demand histological verification of the process which would change the treatment strategy or in case when there is a need for sample for histological examination, i.e. cortical vessel or dura mater. The risk of biopsy is not zero.
Therefore, we should always consider the indication for biopsy. Primary biopsy of spinal cord is not indicated.