Abstract
Castleman's disease is a rare polyclonal lymphoproliferative disease, which becomes manifest as a benign hyperplasia of lymphatic nodes in various localizations and possibly by systemic symptoms. Histopathology provides division into three groups - hyaline-vascular (most frequent), plasma cellular, and mixed.
The clinical manifestation provides a division into unicentric (localized) and multicentric (generalized) form. These variants differ by a clinical course, efficient therapy and prognosis.
Histopathological examination is the method of choice in the diagnosis of Castleman's disease. There has been no standardized therapy so far.
It may be certified, though, that a complete surgical removal of the lymph nodes provides a curative method in the unicentric form. In the multicentric form the systemic therapy is necessary as well.
In our report the case of a 35 years old man with gradually progressing cervical lymphadenopathy is described.