C/EBP gamma is dispensable for steady-state and emergency granulopoiesis

Abstrakt

In summary, the data presented herein demonstrate that specific deletion of Cebpg in the murine hematopoietic system did not alter hematopoietic stem and progenitor cell properties, their ability to commit to the myeloid lineage, and produce granulocytes in normal and stress conditions. As a whole, these surprising observations point to a transcription factor redundancy responsible for controlled production of granulocytes in steady-state and emergency granulopoiesis.

Klíčová slova

• colony-stimulating factor
• enhancer-binding-protein
• deficient mice
• granulocyte
• beta
• cells
• gene