The Effect of Fluid Loading and Hypertonic Saline Solution on Cortical Cerebral Microcirculation ad Glycocalyx Integrity

Abstract

Fluid loading and hyperosmolar solutions can modify the cortical brain microcirculation and the endothelial glycocalyx (EG). This study compared the short-term effects of liberal fluid loading with a restrictive fluid intake followed by osmotherapy with hypertonic saline (HTS) on cerebral cortical microcirculation and EG integrity in a rabbit craniotomy model.

Keywords

• brain
• hypertonic saline
• microcirculation
• osmotherapy
• glycocalyx