Abstract
Rapid and robust antidepressant-like effect of ketamine hydrochloride in subanesthetic doses was already manifested in depressive patients. Maximum of mood improvement was shown within the period from 2 hours to 3 days.
Previous studies proved predictive value of prefrontal QEEG theta cordance reduction after 1 week on a new antidepressant. Congruently with previous findings we hypothesised in our compressed model decrease of prefrontal QEEG theta cordance in 10 minutes of ketamine hydrochloride infusion as the prediction of antidepressant response.