Abstract
In a review author present the state - of the art of diagnostics and therapy of advanced non-small cell lung cancer with ALK and ROSl genes rearrangements. Diagnostic processes are realized in specialized pathologic departments with the help of histology, imunohistochemistry and fluorescent in situ hybridization.
Patients suffering by either with ALK positive NSCLC, or ROSl positive non-small cell lung cancer reach significant benefits from targeted therapy with ALK and ROSl tyrosinkinase inhibitors. In ALK positive advanced non-small cell lung cancer international guidelines recommend to treat with crizotinib, ceritinib or alectinib, while in cases of failure of this therapy, brigatinib should be the second line biologic treatment.
In ROSl positive advanced NSCLC, crizotinib or ceritinib are recommended accordingly to international guidelines. However, in the Czech Republic, there is no approval of those drugs in first line setting.