Body Adiposity Changes After Lifestyle Interventions in Children/Adolescents and the NYD-SP18 and TMEM18 Variants
Abstract
Background: This study was carried out to determine the relationship between the common TMEM-18 (rs4854344, G>T) and NYD-SP18 (rs6971091, G>A) gene variants and weight loss after lifestyle interventions (increased physical activity in conjunction with optimal dietary intake) in overweight/obese children/adolescents. Material/Methods: We genotyped 684 unrelated, white, non-diabetic children (age 12.7 +/- 2.1 years, average BMI at baseline 30.66 +/- 4.80 kg/m(2)).
Anthropometric and biochemical examinations were performed before and after 4 weeks of an intensive lifestyle intervention. Results: The mean weight Loss achieved was 5.20 +/- 2.02 kg (P<0.001).
NYDSP-18 AA homozygotes had significantly higher abdominal skinfold value before and after the intervention (both, P=0.001). No significant associations between BMI decrease and the NYD-SP18 and TMEM18 variants were found.
Associations between all anthropometrical and biochemical changes and genes remained non-significant after data were adjusted for sex, age, and baseline values. Conclusions: Decreased body weight in overweight/obese children is not significantly influenced by the NYD-SP18 rs6971091 or TMEM18 rs4854344 polymorphisms.