A targeted diagnostic procedure and a treatment of an advanced lung carcinoma -the case report of a successful cooperation of four clinic departments, and crizotinib in a treatment of ROS 1 positive NSCLC
2018
Abstract
The authors present a diagnostic procedure and a treatment of 39-year-old non-smoker patient with a metastatic adenocarcinoma of the right upper lobe of lung. Immuno-histochemistry and FISH (fluorescent in situ hybridization) method detected a rearran-gement of ROSÍ gene, CD-74ROS1 variant, as a cancer driver mutation.
The patient was treated with crizotinib as a targeted therapy. Cancer lesions regressed during the therapy.
The residual lesion in the right upper lobe of lung was surgically removed. The patient is in a good clinical condition, she returned to her original work.
She has been receiving a targeted therapy with the first-generation ROS1 inhibitor for 16 months since the ini-tiation of the treatment so far.