Drug solubility and bioavailability improvement. Possible methods with emphasis on liquisolid systems formulation
Abstract
The aim of this book is to provide a brief but comprehensive overview on the issue of drug bioavailability improvement by preparation of a perspective dosage form - liquisolid systems. The introduction chapter about drug solubility and bioavailability is followed by a description of the general methods which could be used to improve drug bioavailability using approaches of chemistry, physical modification, and primarily pharmaceutical technology.
Benefits and practical use of each method are documented by examples. The main part of the book is aimed at characterization and description of liquisolid systems (LSS) - perspective dosage form for bioavailability improvement.
Elementary principles of LSS formulation are described in detail, e.g. how to perform a preformulation study; how to choose the correct type and amount of excipients; how to evaluate the dosage forms, etc. All the above mentioned principles are documented with practical examples.