The effect of co-processed dry binder with microcrystalline cellulose on release of verapamil hydrochloride from hydrophilic matrix tablets
2018
Abstract
The aim of this study was to evaluate the use of co-processed dry binder MicroceLac(R)100 (lactose and microcrystalline cellulose in ratio 3 : 1) and Comprecel(R) 102 (pure microcrystalline cellulose) in formulations for the extended release of verapamil hydrochloride. Hydrophilic matrix tablets containing verapamil hydrochloride, hypromellose and dry binder were prepared by the direct compression method.
Hypromelloses Methocel(TM) K4M Premium CR or Methocel(TM) K100M Premium CR were used as controlled release agents. Release of verapamil hydrochloride from the prepared formulations was studied by the dissolution test method.