Abstract
Glucose control among critically ill patients has been a topic of considerable attention for the past 20 years. there is an ongoing debate regarding the efficacy of blood glucose control in these patients in literature and at scientific meetings with often completely opposite opinions ranging from a strict invasive approach with target glycaemia 4-6 mmol/l to a liberal attitude tolerating even values higher than 12 mmol/l. the objective of the present paper is to describe the current state of knowledge concerning tight glycemic control in the critically ill, to analyse key studies, and to identify reasons for such significant differences in their outcomes. Finally, based on the results of these studies, we would like to suggest future strategies for the monitoring and management of alterations of glycaemia in critically ill patients.