Assessment of Incidence and Character of Neurologic/Neuropsychiatric Complications in a Group of Patients with Malignant Melanoma Treated with Adjuvant High Dose interferon

Abstract

High dose interferon can cause depression and parkinsonism. Prophylaxis with antidepressant medication can keep the incidence of depression as low as 10% or lower.

Development of parkinsonism during HDI is rare. According to available reports, this is the first description of parkinsonism development related to HDI in MM.

Keywords

• malignant melanoma
• high dose interferon
• neurologic and neuropsychiatric complication
• drug-induced depression
• drug-induced parkinsonism