In pheochromocytoma, the secretion of catecholamines is accompanied with various clinical signs and symptoms such as hypertension, headache, palpitations and sweating. In some cases, the clinical course of pheochromocytoma may be disturbed by acute cardiovascular complications such as heart failure or cardiogenic shock, takotsubo cardiomyopathy, myocardial ischaemia, and arrhythmias - tachycardias (supraventricular or ventricular) or less frequently, bradycardias (AV blocks and junctional).
As many of these complications are life-threatening, the most important part of the diagnosis is the awareness of pheochromocytoma as the cause of these clinical situations.