Publication at Faculty of Medicine in Hradec Králové |
2018
Abstract
Epidermolysis bullosa acquisita is a chronic autoimmune blistering disease affecting the skin and mucous membranes. It is characterised by production of IgG auto-antibodies aimed against non-collagen type VII. collagen domain.
A genetic predisposition is likely. The course of the disease is typically gradual and clinically manifests with blisters, scars and milia, especially in areas susceptible to physical trauma.
Therapy includes systemic corticosteroids, anti-inflammatory drugs and immunosuppressives.