Controversial impact of mutational analysis on thyroid fine-needle aspiration biopsies - pilot Study
Abstract
The main aim of our prospective pilot study was the mutational analysis of thyroid nodule aspirates. a four-mutational panel (braF v600e, kras, hras, nras) was chosen. 227 thyroid nodule aspirates of whole bethesda spectrum were analyzed.A mutation was detected in 4,4 %, namely 6 nras mutations and 4 braF mutations, any h-ras or k-ras mutation was found. According to our study we propose a clinical benefit for braF mutational analysis itself, not only it is a papillary thyroid phenotype specific mutation, but it could also serve as a supportive element in treatment strategy. secondly, in a retrospective manner, we scoped our cohort for ultrasonographic features of thyroid nodules and we re-classified them according to the new european eu-tIraDs guideline.
In our case, 13 % less of thyroid nodules would be aspirated, which would lower medical costs as well as spare the patients.