Administration of 500 ml of normal saline does not result in immediate damage to the endothelial glycocalyx determinable by sublingual microcirculation assessment
Abstract
Objective: Assessment of endothelial glycocalyx alteration after infusion of 500 ml of normal saline by perfused boundary region (PBR) parameter in twelve healthy volunteers. Material and method: Twelve healthy volunteers without acute illness were recruited. 500 ml of normal saline was infused to each participant.
We collected basic haemodynamic data as well as perfused boundary region as a marker of endothelial glycocalyx integrity before and after the fluid administration. Student T-test (paired) with p-value of 0.05 was used for the statistical analysis.
Conclusion: Our study did not confirm alteration of the endothelial glycocalyx after intravenous administration of 500 ml normal saline to healthy volunteers. There was a significant decrease of heart rate after the infusion but no other changes were observed.