Publikace na 2. lékařská fakulta |
2018
Abstrakt
We documented for the first time the lncRNA landscape in 44 JMML patients and have associated lncRNA expression with clinical and molecular characteristics. We demonstrated that JMML patients exhibit a distinct lncRNA expression profile compared to healthy controls and different JMML subgroups have distinct lncRNA signatures contributing to disease heterogeneity.
Follow-up studies are needed to confirm the prognostic value of lncRNAs and to perform an integrative analysis of lncRNA expression profiles with mutational patterns, DNA methylation profiles and clinical patients' characteristics. This study paves the way for further functional research on the role of lncRNAs in JMML biology, and their diagnostic and therapeutic application.