Abstract
Most peripheral nerve disorders have a gradual and slow progressive course. But an acute onset may occur with autoimmune andinfectious inflammation, metabolic disorders or intoxication.
Many systemic diseases, as well as drugs, also affect the peripheralnervous system. Peripheral neuropathy typically develops with symmetrical and predominantly distal affections.
The combinationof sensory and motor lesions is the most common, but in some cases motor or sensory abnormalities can predominate, and autonomicsymptoms may also occur. Examination of peripheral nerve disorder involves a careful history, including a family history.It is followed by neurological, electrophysiological and biochemical, serological, immunological, cerebrospinal fluid or genetictests; or imaging.
The most common polyneuropathy in childhood is hereditary motor and sensory neuropathy.