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The Metabolism of 5-methylcytosine Residues in DNA

Publikace |
2018

Tento text není v aktuálním jazyce dostupný. Zobrazuje se verze "en".Abstrakt

The fundamental biochemical processes of 5-methylcytosine (5-mC) synthesis, maintenance, conversion and removal determine the time and spatial pattern of DNA methylation. This has a strong effect on a plethora of physiological aspects of cellular metabolism.

While the presence of 5-mC within the promoter region can silence gene expression, its derivative 5-hydroxymethylcytosine exerts an opposite effect. Dysregulations in the metabolism of 5-mC lead to an altered DNA methylation pattern which is linked with a disrupted epigenome, and are considered to play a significant part in the etiology of several human diseases.

A summary of recent knowledge about the molecular processes participating in DNA methylation pattern shaping is provided here.