Vagus nerve stimulation attenuates multiple organ dysfunction in resuscitated porcine progressive sepsis

Abstract

In a clinically-relevant large animal model of progressive sepsis, vagus nerve stimulation was associated with a number of beneficial effects that resulted in significantly attenuated multiple organ dysfunction and reduced vasopressor and fluid resuscitation requirements. This suggests that vagus nerve stimulation might provide a significant therapeutic potential that warrants further thorough investigation.

Keywords

• organ dysfunction
• pig
• sepsis
• shock
• vagus nerve stimulation