Versatile fluorophores for bioimaging applications: pi-expanded naphthalimide derivatives with skeletal and appendage diversity

Abstract

Four novel fluorescent cores bearing a transformable functional group based on a pi-expanded naphthalimide including a fused pyranone or furan ring have been prepared. Fluorescent probes LysoSers 13-16 for lysosomal targeting have been tested.

Co-localization with a commercial lysosome specific marker confirmed that the LysoSers labeled the lysosomal compartment with high selectivity. The LysoSers show excellent brightness and low toxicity.

Keywords

• fluorescent-probes
• 1,8-naphthalimide
• chemosensors
• trends
• dyes