Publication at Central Library of Charles University |
2019
Abstract
Clozapine has long been considered a gold standard for treatment-resistant schizophrenia. In the first part of the present article we deal with the pharmacokinetic factors that influence the resulting serum level of clozapine and their possible clinical consequences.
In the second part we present the results from therapeutic drug monitoring of clozapine levels in our clinic. The aim of the article is to recall the most important possible interactions that we encounter in clinical practice and to draw attention to the suitability of extending the methods of therapeutic drug monitoring into clinical practice.