Treatment of the great and small saphenous veins with modified cyanoacrylate is one of the most recent techniques. The article discusses the current findings related to cyanoacrylate treatment of varices, the mechanism of cyanoacrylate polymerization and degradation, cyanoacrylate properties, application-related risks, results of available studies, cyanoacrylate toxicity, and its histocompatibility, or findings related to vessel wall reactions to cyanoacrylate.