Abstract
We would like to thank Drs Ulbright and Young for their comment on our articles about pancreatic analog of solid pseudopapillary neoplasm of the testis (11, in which we have describe d a total of 7 testicular tumors that have the morphologic features, immunohistochemical profile (positivity for Beta-catenin, cyclin D1, CD10, CD56, NSE, (often) synaptophysin; uniform negativity for inhibin, calretinin, SF-1, and chromogranin), and oncogenic somatic mutaiton in exon 3 of the CTNNB1 (Beta-catenin) gene identical to those seen in solid pseudopapillary neoplasms (SPNs) of the pancreas (2,3). In addition in a separate article, we have described 13 signet ring cell testicular tumors that have immunohistochemical profile and Beta-catenin mutations identical to those encountered in SPN of the pancreas (4). these 13 testicular tumor were hypothetically likened topancreatic SPN based on the fact that most pancreatic PSNs (20/22) in our files have a signet ring cell component.
We acknowledged that it would need some time to recognize that these 136 signet ring cell tumors of the testis and SPN of the pancreas likely represet the same entity in different anatomic sites.