Negative prognostic significance of primary cilia, CD8 tumor infiltrating lymphocytes and PD1 cells expression in clear cell renal cancer
Abstract
Purpose: The aim of this study was to investigate the potential association and combined prognostic significance of the frequency of primary cilia (PC), programmed cell death protein-1 receptor (PD1) and CD8+ tumor infiltrating lymphocytes (TIL) in patients with clear cell renal cancer (ccRCC). Methods: The frequency of PC, PD1 expression and the frequency of intratumoral CD8+ TIL were evaluated in 104 ccRCC patients.
Results: The median frequency of PC was 0.003. The expression of PD1+ cells were 50% in 5 patients.
Intratumoral CD8+ TIL were evaluable in all patients: negative in 1 patient, 50% in 11 patients. Overall survival (OS) according to the frequency of PC was significantly shorter in patients with higher frequency (>=0.002) than in patients with lower frequency (25%) PD1+ expression than in patients with lower (<25%) expression (4.6 vs. 97. years, p=0.006 and 2.9 vs. 8.9 years, p=0.006, respectively).
Conclusions: The present study provides the first data on the potential association and combined prognostic significance of frequency of PC, PD1+ cells and CD8+ TIL in patients with clear cell renal cancer