Abstrakt
Six albino rabbits were included in an in vivo experiment. Transcorneal intravitreal administrations of carboplatin in healthy albino rabbits were used as a model for possible clinical use in human intraocular retinoblastoma "seeding" tumor chemotherapy.
We administrated 0.05 mg dose of carboplatin intravitreally three times at two-week intervals, Electroretinograms (ERGs) were recorded before first administration of carboplatin and after last injection when also platinum concentration was measured. Reductions in the dark-adapted b-wave amplitudes and in the light-adapted b-wave and a-wave amplitudes and chorioretinal atrophy were noted after treatment.
We considered administered amount of carboplatin probably too high for treatment of retinoblastoma patients.