Abstract
Objective: The aim of this survey was to find out incidence and other circumstances of CNS bleeding in patients with haemophilia A in the Czech Republic. Methods: Data from Czech National Haemophilia Program (CNHP) registry were evaluated.
The findings were compared with available published evidence. Three case reports of CNS bleeding in newborns with haemophilia A are also presented.
Results: CNS bleeding is very rare in patients with haemophilia in Czech Republic - about one out of 1000 bleeding episodes. Patients at any age can be affected, though; bleeds reported between 0 to 79 years.
Up to 5% of newborns with haemophilia A may experience CNS bleeding. Conclusions: CNS bleeding is rare, but serious manifestation of haemophilia.
Clinical manifestation and sequels can be various, from mild to fatal, as demonstrated in case reports. Diagnosis has to be done quickly and proper therapy including factor FVIII substitution should be immediately initiated.
Diagnostics and treatment shall be done only in adequately equipped Haemophilia centre (HTC - Haemophilia Treatment Centre or CCC - Complex Care Centre)