Abstract
Antiphospholipid antibodies bind to the phospholipids or complex protein-phospholipid. The occurrence of those antibodies can lead to the creation of thrombosis or pregnancy disorders that are symptoms of non-inflammatory autoimmune disease - antiphospholipid syndrome.
Main criteria of antiphospholipid syndrome are cardiolipin antibodies and antibodies against ß-2-glycoprotein 1. Other types of antibodies detected in sera of patients are antibodies against phosphatidylserine, phosphatidylethanolamine, prothrombin or annexin V.
Origin and development of those antibodies are not known, and there is ongoing discussion which antibodies are the most present in patients with antiphospholipid syndrome and which ones should be part of main criteria. Therefore, our aim was to observe the occurrence and effect of antiphospholipid antibodies in women with reproductive disorders and their treatment.