Abstract
Multiple system atrophy (MSA) is relatively rare neurodegenerative disease with fatal prognosis affecting middle-aged and elderly individuals. There is combination of several motor and nonmotor symptoms in MSA.
Causal treatment does not exist and symptomatic treatment effect is unsatisfactory. The article briefl y discusses genetics and pathophysiology of MSA with special focus on the clinical picture, practical aspects of diagnostics and current therapeutic options of MSA in the Czech Republic.