Abstrakt
In our previous study, we have demonstrated that primary cutaneous adenoid cystic carcinoma (ACC) manifests genetic changes similar to its salivary gland homologue, including alterations in the MYB and MYBL1 genes.1 Deletion of the 1p36 locus has been shown in salivary gland ACC (range of detection: 0%-44%),2-4 in which this alteration has been found to be associated with reduced overall survival, higher tumor stage, lower recurrence-free interval, lower recurrence-free survival, solid histology, and the absence of MYBL1 break.4,5 As this technique has now become available for us, we investigated our previously published cohort of 10 patients with primary cutaneous ACC.1 FISH for 1p36 was performed, as described elsewhere.5 The analysis was successful in 8 of the 10 cutaneous neoplasms. All the cases, including 2 patients who died of metastatic disease, proved negative.
It seems that the deletion of 1p36 is not a feature of cutaneous ACC, but further studies on larger series are needed to confirm this assumption.