Publication at Faculty of Science |
2019
Abstract
D-serin acts as a coagonist at the glycine site associated with the N-methyl-D-aspartate subtype of glutamate receptors (NMDAR) and has an important modulatory role in major NMDAR-dependent processes. Either over or underfunction of NMDARs may be involved in the pathophysiology of neuropsychiatric disorders.
A first animal and first clinical studies suggest beneficial D-serin effects in treatment schizophrenia, depression and anxiety disorders, and for the improvement of cognitive performance. Thus, the originally curiosity molecule may soon become a significant psychopharmaceutical.