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Branched PLGA derivatives with tailored drug delivery properties

Publication at Faculty of Pharmacy in Hradec Králové |
2020

Abstract

A series of poly(lactic-co-glycolic acid) derivatives with lower molar mass and star or comb architecture were synthesized by a simple, catalyst free, direct melt polycondensation method not requiring purification of the obtained sterile product by precipitation. Branching monomers used were mannitol, pentaerythritol, dipentaerythritol, tripentaerythritol and polyacrylic acid.

The products were characterized by molar mass averages, average branching ratio, rheological and thermal properties.