Publication at Faculty of Pharmacy in Hradec Králové |
2019
Abstract
Alkaloids are of scientific interest due to either their positive or negative effects. This review aims to summarize their antioxidant effects by both classical in vitro scavenging assay and at the cellular level.
Since most in vitro studies used the DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging assay, the results from those studies are summed up in the first part of the article. In the second part, available data on the effect of alkaloids on NADPH-oxidase, the key enzyme for reactive oxygen species production, at the cellular level, are summarized.