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Synthesis of 13,14-Dehydro-prostaglandins Synthetic Analogues: A Review

Publication at Faculty of Pharmacy in Hradec Králové |
2019

Abstract

Prostaglandins (PG) are a group of lipid mediators with several biological activities. Their structure includes a five-membered ring and two lateral chains (alpha and omega- chains).

Due to their pharmaceutical and veterinary applications numerous synthetic analogues have been prepared and are described in literature. 13,14-dehydroPG are synthetic analogues including a triple bond in their skeleton which provide them a more preferable biological behaviour. However, these compounds require special approaches for their synthesis and attachment of its omega-chain when compared with allylic PG (double bond at position 13-14 of PG numbering).

This review intends to summarize available strategies for the introduction of the omega-chains when a triple bond moiety (at position C13-14) is present.