A rare example of syndromic autism is autism spectrum disorder (ASD) in children with brain tumors. The case reports on this association are few and mostly involve autism and cerebellar pilocytic astrocytoma (Omar et al. 2009; Adachi et al. 2012; Minhas et al. 2013), right temporal ganglioglioma (Mikati et al. 2009), and mesial temporal oligodendroglioma (Hoon and Reiss 1992).
The majority of the described cases underwent neurosurgery for removal of the brain tumor (Adachi et al. 2012; Minhas et al. 2013; Mikati et al. 2009; Hoon and Reiss 1992). Following surgery, autism remained unchanged (Adachi et al. 2012), was minimally or mildly improved (Hoon and Reiss 1992; Mikati et al. 2009), or autism improvement was not specified (Minhas et al. 2013).