PLASMA LEVELS OF HSP90 ARE INCREASED IN INTERSTITIAL LUNG DISEASE AND SKIN FIBROSIS IN PATIENTS WITH SYSTEMIC SCLEROSIS
Abstract
We demonstrated higher plasma levels of Hsp90 in SSc patientscompared to healthy controls. Concentrations of extracellular Hsp90 increasewith higher inflammatory activity, with deteriorated lung functions in ILD and alsowith the extent and severity of the skin involvement in patients with diffuse cutane-ous SSc.
These data further highlight the role of Hsp90 as a significant regulatorof fibroblast activation and tissue fibrosis in SSc.