The influence of microbial isoflavonoid specific metabolites on platelets and transition metals iron and copper
2019
Abstract
Isoflavonoids are metabolized by human microflora into small phenolic compounds including equol, O-desmethylangolensin, 2-(4-hydroxyphenyl) propionic acid (HPPA) and 4-ethylphenol. In this study we analyzed their effects on platelet aggregation in human blood encompassing the analysis of the mechanism of action; and their interaction with transition metals iron and copper at different pathophysiologically relevant pH conditions.