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The influence of microbial isoflavonoid specific metabolites on platelets and transition metals iron and copper

Publication at Faculty of Pharmacy in Hradec Králové |
2019

Abstract

Isoflavonoids are metabolized by human microflora into small phenolic compounds including equol, O-desmethylangolensin, 2-(4-hydroxyphenyl) propionic acid (HPPA) and 4-ethylphenol. In this study we analyzed their effects on platelet aggregation in human blood encompassing the analysis of the mechanism of action; and their interaction with transition metals iron and copper at different pathophysiologically relevant pH conditions.