The Effect of Silymarin Flavonolignans and Their Sulfated Conjugates on Platelet Aggregation and Blood Vessels Ex Vivo

Abstract

Silymarin is a popular over-the-couter drug and food supplement. However, only limited data are available on its cardiovascular effects.

In this study, we analyzed the vasorelaxant and antiplatelet effects of a row of pure isolated silymarin flavonolignans and their sulphated metabolites.

Keywords

• milk thistle
• Silybum marianum
• sulfates
• metabolites
• vasorelaxant
• aorta
• thrombocytes
• blood coagulation